Health Library Explorer
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z A-Z Listings Contact Us
Neurological
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Back to Intro
Click a letter to see a list of medical procedures beginning with that letter.
Click 'Back to Intro' to return to the beginning of this section.

Diamond Blackfan Anemia (DBA) in Children

What is DBA in children?

Diamond Blackfan anemia (DBA) is a rare blood disorder. Children with DBA don't make enough red blood cells. These cells carry oxygen to all other cells in the body.

Blood cells are made in the bone marrow, the spongy insides of long bones. In children with DBA, many of the cells that would have become red blood cells die before they develop.

What causes DBA in a child?

DBA may be passed down through families. About half of children with this disorder have a gene defect. In the other half, no gene defects are found and the cause isn't known.

What are the symptoms of DBA in a child?

Most of the time, symptoms of anemia appear by the time a child is 2 months old. Symptoms may range from mild to severe. They include:

  • Pale skin

  • Sleepiness

  • Being grouchy (irritability)

  • Rapid heartbeat

  • Heart murmur

  • Physical defects of the face, head, neck, hands and arms, kidneys, penis, and heart

  • Low birth weight

How is DBA diagnosed in a child?

The diagnosis of DBA is often made in the first year of life. It's diagnosed based on symptoms, and on the results of blood and bone marrow testing.

 Anemia is diagnosed with:

  • Hemoglobin and hematocrit.  This blood test measures the amount of hemoglobin and red blood cells in the blood.

  • Complete blood count (CBC). This test checks the red blood cells, white blood cells, and blood clotting cells (platelets). It sometimes checks young red blood cells (reticulocytes). It includes hemoglobin and hematocrit and more details about the red blood cells.

  • Peripheral smear. A small sample of blood is checked under a microscope to see if the cells look normal or not.

  • Bone marrow analysis. A sample of bone marrow cells is taken and examined.

Diagnosis of DBA is based on these 4 results from a complete blood count (CBC) and bone marrow biopsy:

  • Anemia before 1 year of age

  • Red blood cells are larger than normal (macrocytic anemia)

  • Low reticulocyte count, which are new red blood cells

  • Bone marrow sample with only a few cells that will develop into red blood cells

Other lab tests may also be abnormal. And genetic testing may show gene defects or changes.

How is DBA treated in a child?

Treatment may include medicines, blood transfusions, and bone marrow transplant. DBA was once thought of as a children’s disease. But with more successful treatments, many children live well into adulthood. Many more adults now are living with the disease.

Specialists treat children with DBA. Your child's healthcare provider may advise seeing a blood specialist (hematologist), or a gene specialist (geneticist), or other experts. DBA is treated with:

  • Corticosteroid or steroid medicines. Steroids improve red blood cell counts in about 80% of people with DBA. Steroids are strong medicines with some serious side effects. Your child's provider will watch for side effects and use as low a dose as possible.

  • Blood transfusions.  Donor blood may be given every 4 to 6 weeks to increase the red blood cell count.

  • Stem cell transplant.  Stem cells are cells in the bone marrow that can become all types of blood cells. First a matched donor is found. This is usually a close family member. Then the donor’s stem cells are given to the person with DBA. A stem cell transplant may cure DBA. But rejection or infection is possible. These risks are serious. So stem cell transplant is usually not done unless steroids or blood transfusions don’t help.

About 20% of people with DBA go into remission after treatment. Remission means that the symptoms of anemia have disappeared for more than 6 months. Remission can last for many years and can even be lasting (permanent). If symptoms come back after remission, it's called relapse.

What are possible complications of DBA in a child?

Complications of DBA include:

  • Slow or delayed growth

  • Problems with pregnancy

  • Problems related to physical defects (for instance, heart problems)

  • Leukemia and other cancers

Some complications from the treatment of DBA include:

  • Problems from long-term steroid use. These can include osteoporosis, weight gain, high blood pressure, and diabetes.

  • Iron overload. This is a complication of blood transfusions. It can affect the heart and liver.

How can I help my child live with DBA?

Your child will be watched very closely. They'll have:

  • Frequent physical exams and lab tests

  • More frequent screenings for cancer

  • Genetic counseling for you, your child, and other brothers and sisters. This is very important before any pregnancy.

Severe anemia in a child affects the whole family. You should:

  • Learn as much as possible about DBA.

  • Work closely with your child's healthcare provider.

  • Help your child take part in school, social, and physical activities.

  • Work closely with your child’s school to make sure they get what's needed. Your child may also qualify for special programs under Section 504 of the Rehabilitation Act of 1973.

  • Try to keep your child's life as normal as possible.

  • Remember to also pay attention to other children in the family.

When should I call my child's healthcare provider?

You know your child better than anyone else. If you're in doubt or if you have questions or concerns, it's best to contact their provider.

And, work closely with your child's provider to know what to report. It depends on your child's age, treatment, and other factors. For instance, the provider will tell you what to watch for if your child has had a stem cell transplant. Or if your child is taking a certain medicine, the provider will tell you what side effects may occur. 

Key points about DBA in children

  • DBA is a rare blood disorder in which children don't make enough red blood cells. These are the cells that carry oxygen to all other cells in the body.

  • About half of children with DBA have a genetic mutation. Genetic counseling is advised.

  • It's often diagnosed during the first year of life with blood and bone marrow tests.

  • DBA is treated with corticosteroids and blood transfusions.

  • Stem cell transplants offer a cure for DBA.

Next steps

Tips to help you get the most from a visit to your child’s healthcare provider:

  • Know the reason for the visit and what you want to happen.

  • Before your visit, write down questions you want answered.

  • At the visit, write down the name of a new diagnosis, and any new medicines, treatments, or tests. Also write down any new instructions your provider gives you for your child.

  • Know why a new medicine or treatment is prescribed and how it will help your child. Also know what the side effects are.

  • Ask if your child’s condition can be treated in other ways.

  • Know why a test or procedure is recommended and what the results could mean.

  • Know what to expect if your child does not take the medicine or have the test or procedure.

  • If your child has a follow-up appointment, write down the date, time, and purpose for that visit.

  • Know how you can contact your child’s provider after office hours. This is important if your child becomes ill and you have questions or need advice.

Online Medical Reviewer: Adam Levy MD
Online Medical Reviewer: Amy Finke RN BSN
Online Medical Reviewer: L Renee Watson MSN RN
Date Last Reviewed: 3/1/2022
© 2000-2024 The StayWell Company, LLC. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.
Contact Our Health Professionals
Follow Us
Facebook Twitter YouTube LinkedIn Pinterest Google Plus
View Disclaimer